An optical fiber having both low macrobend loss and low microbend loss. The fiber has a first inner cladding region having an outer radius r2>8 microns and refractive index Δ2 and a second outer cladding region surrounding the inner cladding region having refractive index Δ4, wherein Δ1>Δ4>Δ2. The difference between Δ4 and Δ2 is greater than 0.002 percent. The fiber exhibits a 22 m cable cutoff less than or equal to 1260 nm, and r1/r2 is greater or equal to 0.25.