Systems and methods are provided for power measurement of signals such that the power measurement is insensitive to PVT variations of the measurement systems. A power measurement system includes an analog squarer circuitry, an integrating ADC, and a controller. The squarer circuitry calculates the power of a signal whose power is to be measured while the integrating ADC integrates the calculated power over a runup interval to generate an integrated power. The squarer circuitry also calculates the power of a reference for the integrating ADC to de-integrate the integrated power over a rundown interval. The power measurements are independent of PVT variations of the analog squarer circuitry and integrating ADC. The controller digitally controls the runup interval and measures the rundown interval to provide digitized power measurements. The analog squarer circuitry have replica squarer circuits. Process dependent mismatches between the replica analog circuitry may be removed through a calibration process.