Methods, apparatus and articles of manufacture for hierarchical anomaly localization and prioritization are disclosed. An example method disclosed herein comprises obtaining reported status for a plurality of nodes of a hierarchical topology, the reported status for a particular node being at least one of normal, abnormal or indeterminate, and determining a subset of root cause abnormal nodes, a root cause abnormal node included in the subset of root cause abnormal nodes having a total number of abnormal direct descendent nodes and indeterminate direct descendent nodes that is greater than a number of normal direct descendent nodes of the root cause abnormal node.