发明申请
- 专利标题： METHOD FOR CULTIVATING A TRANSGENIC ANIMAL WITH INCREASED EXPRESSION AMOUNT OF PORCINE GROWTH HORMONE
- 专利标题（中）： 用于增加转化生长激素表达量的转基因动物的方法
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申请号： US13122400申请日： 2010-06-24
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公开(公告)号： US20130053628A1公开(公告)日： 2013-02-28
- 发明人: Kui Li , Huiming Ju , Xinmin Zheng , Lijing Bai , Wentao Cui , Zhonglin Tang , Yulian Mu , Shulin Yang
- 申请人： Kui Li , Huiming Ju , Xinmin Zheng , Lijing Bai , Wentao Cui , Zhonglin Tang , Yulian Mu , Shulin Yang
- 申请人地址： CN Beijing
- 专利权人： Institute of Animal Science, Chinese Academy of Agricultural Sciences
- 当前专利权人： Institute of Animal Science, Chinese Academy of Agricultural Sciences
- 当前专利权人地址： CN Beijing
- 优先权： CN201010102427.4 20100127
- 国际申请： PCT/CN10/00942 WO 20100624
- 主分类号： C12N15/85
- IPC分类号： C12N15/85 ; A61B17/435
摘要：
A method for cultivating a transgenic animal with an increased expression amount of porcine growth hormone is provided. Additionally, a method for cultivating a transgenic embryo, which introduces a recombinant expression vector of 1) TRE-GH or 2) TET-ON into a target embryo to obtain a transgenic embryo with a higher expression amount of porcine growth hormone than a target embryo without introduction is provided. A transgenic animal can be obtained by transplanting the embryo into an animal. The experiments demonstrate that growth hormone (GH) is sharply increased in blood of transgenic pigs after adding DOX.
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