发明申请
- 专利标题： HIGH AFFINITY NY-ESO T CELL RECEPTORS
- 专利标题（中）： 高亲属性NY-ESO T细胞受体
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申请号： US13429944申请日： 2012-03-26
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公开(公告)号： US20130058908A1公开(公告)日： 2013-03-07
- 发明人: Jonathan Michael Boulter , Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn
- 申请人： Bent Karsten Jakobsen , Yi Li , Peter Eamon Molloy , Steven Mark Dunn
- 优先权： GB0411123.3 20040519; GB0419643.2 20040903
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61P35/00 ; A61K35/14 ; C07K19/00 ; C12N5/10
摘要：
The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.
公开/授权文献
- US09156903B2 High affinity NY-ESO T cell receptors 公开/授权日：2015-10-13
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