Signatures that can be used to identify video and audio content are generated from the content by generating measures of dissimilarity between features of corresponding groups of pixels in frames of video content and by generating low-resolution time-frequency representations of audio segments. The signatures are generated by applying a hash function to intermediate values derived from the measures of dissimilarity and to the low-resolution time-frequency representations. The generated signatures may be used in a variety of applications such as restoring synchronization between video and audio content streams and identifying copies of original video and audio content. The generated signatures can provide reliable identifications despite intentional and unintentional modifications to the content.