发明申请
- 专利标题： METHOD FOR BREAST CANCER RECURRENCE PREDICTION UNDER ENDOCRINE TREATMENT
- 专利标题（中）： 乳腺癌复发预后的方法
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申请号： US13638360申请日： 2011-03-29
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公开(公告)号： US20130065786A1公开(公告)日： 2013-03-14
- 发明人: Mareike Dartmann , Inke Sabine Feder , Mathias Gehrmann , Guido Hennig , Karsten Weber , Christian Von Törne , Ralf Kronenwett , Christoph Petry
- 申请人： Mareike Dartmann , Inke Sabine Feder , Mathias Gehrmann , Guido Hennig , Karsten Weber , Christian Von Törne , Ralf Kronenwett , Christoph Petry
- 申请人地址： DE Cologne
- 专利权人： Sividon Diagnostics GmbH
- 当前专利权人： Sividon Diagnostics GmbH
- 当前专利权人地址： DE Cologne
- 优先权： EP10158561.0 20100331
- 国际申请： PCT/EP2011/054855 WO 20110329
- 主分类号： C40B30/04
- IPC分类号： C40B30/04 ; C40B40/06 ; C12Q1/68
摘要：
The present invention relates to methods, kits and systems for the prognosis of the disease outcome of breast cancer, said method comprising: (a) determining in a tumor sample from said patient the RNA expression levels of at least 2 of the following 9 genes: UBE2C, BIRC5, RACGAP1, DHCR7, STC2, AZGP1, RBBP8, IL6ST, and MGP (b) mathematically combining expression level values for the genes of the said set which values were determined in the tumor sample to yield a combined score, wherein said combined score is indicative of a prognosis of said patient; and kits and systems for performing said method.