发明申请
US20130065902A1 3-(HETEROARYL-AMINO)-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS
有权
3-（异丁基氨基）-1,2,3,4-四氢-9H-卡波醇衍生物及其作为PROSTAGLANDIN D2受体调节剂的用途
- 专利标题： 3-(HETEROARYL-AMINO)-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS
- 专利标题（中）： 3-（异丁基氨基）-1,2,3,4-四氢-9H-卡波醇衍生物及其作为PROSTAGLANDIN D2受体调节剂的用途
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申请号： US13637005申请日： 2011-03-21
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公开(公告)号： US20130065902A1公开(公告)日： 2013-03-14
- 发明人: Hamed Aissaoui , Heinz Fretz , Julien Hazemann , Sylvia Richard-Bildstein , Romain Siegrist
- 申请人： Hamed Aissaoui , Heinz Fretz , Julien Hazemann , Sylvia Richard-Bildstein , Romain Siegrist
- 申请人地址： CH Allschwil
- 专利权人： Actelion Pharmaceuticals Ltd.
- 当前专利权人： Actelion Pharmaceuticals Ltd.
- 当前专利权人地址： CH Allschwil
- 优先权： IBPCT/IB2010/051228 20100322
- 国际申请： PCT/IB2011/051165 WO 20110321
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; C07D413/12 ; A61K31/423 ; C07D417/12 ; A61K31/428 ; A61K31/517 ; C07D401/12 ; A61K31/4439 ; A61K31/422 ; A61K31/498 ; A61K31/427 ; A61K31/4155 ; A61K31/433 ; A61P35/02 ; A61P11/06 ; A61P37/00 ; A61P37/08 ; A61P11/02 ; A61P13/12 ; A61P17/00 ; A61P1/04 ; A61P1/00 ; A61P19/02 ; A61P29/00 ; C07D403/12
摘要：
The present invention relates to 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9H-carbazole derivatives of the formula (I), wherein R1, R2 and R3 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.