A schedule manager may include a chromosome comparator configured to compare a plurality of schedule chromosomes, each schedule chromosome including a potential schedule of use of manufacturing resources within one or more time intervals in producing one or more items, and configured to compare each of the plurality of schedule chromosomes relative to constraints, to thereby output a selected subset of the plurality of schedule chromosomes. The schedule manager may include a chromosome combiner configured to combine schedule chromosomes of the selected subset to obtain a next generation of schedule chromosomes for output to the chromosome comparator and for subsequent comparison therewith of the next generation of schedule chromosomes with respect to the constraints, as part of an evolutionary loop of the plurality of schedule chromosomes between the chromosome comparator and the chromosome combiner, and a scheduler configured to select a selected schedule chromosome therefrom.