发明申请
US20130072543A1 Compounds and Compositions for Nucleic Acid Formulation and Delivery
审中-公开
用于核酸配方和递送的化合物和组合物
- 专利标题： Compounds and Compositions for Nucleic Acid Formulation and Delivery
- 专利标题（中）： 用于核酸配方和递送的化合物和组合物
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申请号： US13541891申请日： 2012-07-05
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公开(公告)号： US20130072543A1公开(公告)日： 2013-03-21
- 发明人: Michael J. Bennett , John Frederick Boylan , Wei He
- 申请人： John Frederick Boylan , Wei He
- 申请人地址： US CA Pasadena
- 专利权人： ARROWHEAD RESEARCH CORPORATION
- 当前专利权人： ARROWHEAD RESEARCH CORPORATION
- 当前专利权人地址： US CA Pasadena
- 主分类号： A61K47/22
- IPC分类号： A61K47/22
摘要：
The invention relates to compositions containing compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, and n are defined in the detailed description and claims. In addition, the present invention relates to novel formulations containing compounds of formula I for improved delivery of nucleic acids such as siRNA to the cytoplasm of target cells. In particular embodiments these formulations comprise compounds of formula I, phospholipids, cholesterol, and pegylated lipids. The present invention also relates to methods of manufacturing and using such compounds and compositions.
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