发明申请
- 专利标题： USE OF POLYOLS TO OBTAIN STABLE POLYMORPHOUS FORMS OF RIFAXIMIN
- 专利标题（中）： 使用多元醇获得稳定的多晶型多晶型
-
申请号： US13544945申请日： 2012-07-09
-
公开(公告)号： US20130072676A1公开(公告)日： 2013-03-21
- 发明人: Paola MAFFEI , Milena BACHETTI , Giuseppe BOTTONI , Giuseppe Claudio VISCOMI
- 申请人： Paola MAFFEI , Milena BACHETTI , Giuseppe BOTTONI , Giuseppe Claudio VISCOMI
- 申请人地址： IT Bologna
- 专利权人： ALFA WASSERMANN, S.P.A.
- 当前专利权人： ALFA WASSERMANN, S.P.A.
- 当前专利权人地址： IT Bologna
- 优先权： ITMI2006A001692 20060905
- 主分类号： C07D498/18
- IPC分类号： C07D498/18
摘要：
Polyols stabilize polymorphous form of rifaximin, in particular the β form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph β is stable and remains stable in time independently from the environment humidity.In this invention a method to prepare formulations constituted by pure and stable polymorphous forms able to give a pharmaceutical product is described.
公开/授权文献
信息查询
