Invention Application
- Patent Title: BENZOXAZEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
- Patent Title (中): 苯唑西汀PI3K抑制剂化合物及其使用方法
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Application No.: US13681763Application Date: 2012-11-20
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Publication No.: US20130079331A1Publication Date: 2013-03-28
- Inventor: Nicole Blaquiere , Steven Do , Danette Dudley , Adrian Folkes , Robert Heald , Timothy Heffron , Mark Jones , Aleksandr Kolesnikov , Chudi Ndubaku , Alan G. Olivero , Stephen Price , Steven Staben , Lan Wang
- Applicant: GENENTECH, INC.
- Applicant Address: US CA South San Francisco
- Assignee: GENENTECH, INC.
- Current Assignee: GENENTECH, INC.
- Current Assignee Address: US CA South San Francisco
- Main IPC: C07D498/04
- IPC: C07D498/04

Abstract:
Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2 or N; Z3 is CR3 or N; Z4 is CR4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring fused to the benzoxepin ring, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Public/Granted literature
- US08586574B2 Benzoxazepin PI3K inhibitor compounds and methods of use Public/Granted day:2013-11-19
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