发明申请
- 专利标题: ECT2 PEPTIDES AND VACCINES INCLUDING THE SAME
- 专利标题(中): ECT2肽和疫苗,包括它们
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申请号: US13638272申请日: 2011-03-30
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公开(公告)号: US20130095128A1公开(公告)日: 2013-04-18
- 发明人: Yusuke Nakamura , Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa Watanabe
- 申请人: Yusuke Nakamura , Takuya Tsunoda , Ryuji Ohsawa , Sachiko Yoshimura , Tomohisa Watanabe
- 申请人地址: JP KANAGAWA
- 专利权人: ONCOTHERAPY SCIENCE INC
- 当前专利权人: ONCOTHERAPY SCIENCE INC
- 当前专利权人地址: JP KANAGAWA
- 国际申请: PCT/JP2011/001909 WO 20110330
- 主分类号: C07K7/06
- IPC分类号: C07K7/06
摘要:
Isolated peptides derived from SEQ ID NO: 42 and fragments thereof that bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines, are described herein. The inventive peptides encompass both the afore-mentioned amino acid sequences and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted or added, provided such modified versions retain the requisite HLA binding and/or CTL inducibility of the original sequences. Further provided are nucleic acids encoding any of the aforementioned peptides as well as pharmaceutical agents, substances and/or compositions that include or incorporate any of the aforementioned peptides or nucleic acids. The peptides, nucleic acids, pharmaceutical agents, substances and compositions of this invention find particular utility in the treatment of cancers and tumors, including, for example, bladder cancer, breast cancer, cervical cancer, cholangiocellular carcinoma, CML, colorectal cancer, esophageal cancer, NSCLC, lymphoma, pancreatic cancer, prostate cancer, renal carcinoma and SCLC.
公开/授权文献
- US08951975B2 ECT2 peptides and vaccines including the same 公开/授权日:2015-02-10
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