发明申请
US20130096303A1 PROCESS FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATES THEREOF
有权
制备HMG-COA还原酶抑制剂及其中间体的方法
- 专利标题： PROCESS FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATES THEREOF
- 专利标题（中）： 制备HMG-COA还原酶抑制剂及其中间体的方法
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申请号： US13806626申请日： 2011-06-30
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公开(公告)号： US20130096303A1公开(公告)日： 2013-04-18
- 发明人: Hyun Ju , Sang-Sun Joung , Hyun-Jik Yi , Ja-Heouk Khoo , Jong-Chul Lim , Jae-Gyu Kim
- 申请人： Hyun Ju , Sang-Sun Joung , Hyun-Jik Yi , Ja-Heouk Khoo , Jong-Chul Lim , Jae-Gyu Kim
- 优先权： KR10-2010-0063604 20100701
- 国际申请： PCT/KR11/04783 WO 20110630
- 主分类号： C07D239/69
- IPC分类号： C07D239/69 ; C07D215/14 ; C07D405/06 ; C07D209/18
摘要：
The present invention provides an improved process for preparing HMG-CoA reductase inhibitors such as rosuvastatin calcium, fluvastatin sodium, and pitavastatin calcium under a mild condition, using a novel amide-bond-containing compound having R2—N—O—R1 moiety as a key intermediate. And also, the present invention provides the novel compound, an intermediate useful for the preparation thereof, and a process for the preparation thereof.
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