Embodiments of the present invention provide a system for secure error detection and synchronous data tagging for high-speed data transfer (e.g., utilizing a set of SSD memory disk units). Specifically, in a typical embodiment, the system comprises a SSD memory disk unit in communication with a device driver. A first encoded communication stream will be generated with the device driver and sent via PCI-based channel (e.g., full duplex) to the SSD memory disk unit. The stream is received, synchronized, and decoded on the SSD memory disk unit. In turn, the SSD memory disk unit can generate and send a second encoded communication steam to the device driver.