A multi-functional patient transfer device for transferring mobility-impaired patients is disclosed. The multi-functional patient transfer device may include a lift cart and one or more lift components. The lift components may attach to the lift cart and/or other lift components. The lift components may include frontal bars, a tabletop, a central arm, lifting forks, a hoist, a knee blocker, footrests, a transfer chair, detachable handles, and/or safety cushions. The device may include one or more patient interfaces. The patient interfaces may attach to the lift cart and/or one or more lifting components. The patient interfaces may include slings, chairs, straps, harnesses, and/or transfer sheets. The patient interfaces may include foldable panels. The patient interfaces may include a buttock/link support. Methods of the present invention may include frontal transfers, lateral seated transfers, lateral bed transfers, and sit-to-stand transitions.