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发明申请
US20130122526A1 METHOD OF PREPARING A FUSION PROTEIN FOR THE INHIBITION OR REDUCTION OF SECRETION OF AN EXTRACELLULAR MEDIATOR FROM A TARGET CELL 审中-公开
用于抑制或减少来自目标细胞的细胞外介质分泌的融合蛋白的方法

  • 专利标题： METHOD OF PREPARING A FUSION PROTEIN FOR THE INHIBITION OR REDUCTION OF SECRETION OF AN EXTRACELLULAR MEDIATOR FROM A TARGET CELL
  • 专利标题（中）： 用于抑制或减少来自目标细胞的细胞外介质分泌的融合蛋白的方法
  • 申请号： US13528762
    申请日： 2012-06-20
  • 公开(公告)号： US20130122526A1
    公开(公告)日： 2013-05-16
  • 发明人: Keith Foster , John Chaddock , Charles Penn
  • 申请人： Keith Foster , John Chaddock , Charles Penn
  • 申请人地址： GB Salisbury
  • 专利权人： SYNTAXIN LIMITED
  • 当前专利权人： SYNTAXIN LIMITED
  • 当前专利权人地址： GB Salisbury
  • 优先权： GB0321344.4 20030911
  • 主分类号： C12N9/52
  • IPC分类号： C12N9/52
METHOD OF PREPARING A FUSION PROTEIN FOR THE INHIBITION OR REDUCTION OF SECRETION OF AN EXTRACELLULAR MEDIATOR FROM A TARGET CELL
摘要：
The present invention provides a method for designing a re-targeted toxin conjugate for use in treating a medical condition or disease. Also provided, is the use of said conjugates in the manufacture of a medicament for treating medical conditions or diseases. The conjugates include a Targeting Moiety, which directs the conjugate to a desired target cell, and are characterised by a Targeting Moiety that increases exocytic fusion in the target cell. The present invention also provides methods for identifying agonists suitable for use as Targeting Moieties, and methods for preparing conjugates comprising said Targeting Moieties.
摘要（中）：

本发明提供了一种用于设计用于治疗医学病症或疾病的再靶向毒素缀合物的方法。 还提供了所述缀合物在制备用于治疗医学病症或疾病的药物中的用途。 缀合物包括将缀合物引导至期望的靶细胞的靶向部位，其特征在于靶细胞增加靶细胞中的胞外融合。 本发明还提供了用于鉴定适合用作靶向部分的激动剂的方法，以及制备包含所述靶向部分的缀合物的方法。

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