发明申请
- 专利标题: METHODS AND COMPOSITIONS FOR TREATING CANCER
- 专利标题(中): 用于治疗癌症的方法和组合物
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申请号: US13520472申请日: 2011-01-10
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公开(公告)号: US20130123328A1公开(公告)日: 2013-05-16
- 发明人: Qiang Yu , Jing Tan
- 申请人: Qiang Yu , Jing Tan
- 申请人地址: SG Singapore
- 专利权人: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- 当前专利权人: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- 当前专利权人地址: SG Singapore
- 优先权: SG201000114-7 20100108; SG201001629-3 20100304
- 国际申请: PCT/SG11/00011 WO 20110110
- 主分类号: C12Q1/68
- IPC分类号: C12Q1/68 ; A61K31/436 ; C12Q1/42 ; A61K45/06 ; G01N33/68 ; A61K31/506 ; A61K31/713
摘要:
We describe a method of determining whether a cancer cell is likely to be resistant to treatment by an mTOR inhibitor. The method may comprise detecting PPP2R2B (GenBank Accession Number: NM_18167) in or of the cell. It may, alter-natively, or in addition, comprise detecting PDK1 (GenBank Accession Number: NM_002613), in or of the cell. The method may comprise detecting methylation of the PPP2R2B promoter in or of the cell. It may comprise detecting the expression and/or activity of PPP2R2B in or of the cell. It may comprise detecting PDK1 mediated Myc phosphorylation activity. Methods of choosing a treatment for an individual suffering from or suspected to be suffering from a cancer, determining whether an individual suffering from or suspected to be suffering from a cancer will respond to treatment by an mTOR inhibitor, increasing the sensitivity of a cancer cell to treatment by an mTOR inhibitor, for treating or preventing cancer in an individual suffering or suspected to be suffering from cancer are also provided. We further provide for a combination of an inhibitor of PDK1 expression and/or activity and an mTOR inhibitor for use in a method of treatment or prevention of cancer.
公开/授权文献
- US09249466B2 Methods and compositions for treating cancer 公开/授权日:2016-02-02