An illuminated medical tubing set that provides visual indications of characteristics relating to the type and operating status of the tubing. An illuminated tubing set system generally comprises an optical element, a fluid conduit, and a power source. In general, the fluid conduit is used to transmit fluid in a critical care environment. The power source interfaces with the optical element. The optical element is configured to illuminate the tubing set after being powered by the power source. Optionally, the illuminated tubing set can further comprise a pressure sensor and a microcontroller. Additional sensors, such as to monitor other characteristics of the tubing, fluid, or surrounding environment, can also be included. For example, an occlusion sensor, temperature sensor, or flow sensor, or any combination thereof, can be included.