发明申请
US20130131018A1 SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS
审中-公开
取代的异喹啉及其作为管状体聚合抑制剂的用途
- 专利标题： SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS
- 专利标题（中）： 取代的异喹啉及其作为管状体聚合抑制剂的用途
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申请号： US13701917申请日： 2011-06-01
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公开(公告)号： US20130131018A1公开(公告)日： 2013-05-23
- 发明人: Bertrand Leblond , Thierry Taverne , Eric Beausoleil , Cédric Chauvignac , Anne-Sophie Casagrande , Laurent Desire
- 申请人： Bertrand Leblond , Thierry Taverne , Eric Beausoleil , Cédric Chauvignac , Anne-Sophie Casagrande , Laurent Desire
- 申请人地址： FR Paris
- 专利权人： Exonhit S.A.
- 当前专利权人： Exonhit S.A.
- 当前专利权人地址： FR Paris
- 优先权： EP10305605.7 20100604; EP10170684.4 20100723
- 国际申请： PCT/EP2011/059157 WO 20110601
- 主分类号： C07D217/20
- IPC分类号： C07D217/20 ; A61K31/437 ; A61K31/472 ; A61K45/06 ; C07D498/04 ; C07D401/10 ; C07D405/10 ; A61K31/4725 ; A61K31/675 ; C07F9/62
摘要：
The present invention relates generally to substituted isoquinolines and their use as tubulin polymerization inhibitors. In particular, the invention relates to substituted isoquinolines which possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.
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