发明申请
US20130137690A1 4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS
审中-公开
4-羧基苯甲酰胺衍生物作为脱乙酰壳多糖酶抑制剂
- 专利标题： 4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS
- 专利标题（中）： 4-羧基苯甲酰胺衍生物作为脱乙酰壳多糖酶抑制剂
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申请号： US13751789申请日： 2013-01-28
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公开(公告)号： US20130137690A1公开(公告)日： 2013-05-30
- 发明人: Paul Harrington , Richard W. Heidebrecht, JR. , Solomon Kattar , Thomas A. Miller , Karin M. Otte , Phieng Siliphaivanh , Matthew G. Stanton , Paul Tempest , Kevin J. Wilson , David J. Witter
- 申请人： Paul Harrington , Richard W. Heidebrecht, JR. , Solomon Kattar , Thomas A. Miller , Karin M. Otte , Phieng Siliphaivanh , Matthew G. Stanton , Paul Tempest , Kevin J. Wilson , David J. Witter
- 主分类号： C07D295/155
- IPC分类号： C07D295/155 ; A61K31/5377 ; C07D213/55 ; C07D403/02 ; C07D413/14 ; A61K31/496 ; C07D409/14
摘要：
The present invention relates to a novel class of 4-carboxybenzylamino derivatives. The 4-carboxybenzylamino compounds can be used to treat cancer. The 4-carboxybenzylamino compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the 4-carboxybenzylamino derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the 4-carboxybenzylamino derivatives in vivo.
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