Invention Application
US20130149783A1 CLEAVABLE MODIFICATIONS TO REDUCIBLE POLY (AMIDO ETHYLENIMINES)S TO ENHANCE NUCLEOTIDE DELIVERY
审中-公开
可减少聚氨酯（AMIDO乙烯）的改进可以提高核子递送
- Patent Title: CLEAVABLE MODIFICATIONS TO REDUCIBLE POLY (AMIDO ETHYLENIMINES)S TO ENHANCE NUCLEOTIDE DELIVERY
- Patent Title (中): 可减少聚氨酯（AMIDO乙烯）的改进可以提高核子递送
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Application No.: US13635479Application Date: 2011-03-16
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Publication No.: US20130149783A1Publication Date: 2013-06-13
- Inventor: James William Yockman , Jonathan H. Brumbach , Sung Wan Kim
- Applicant: James William Yockman , Jonathan H. Brumbach , Sung Wan Kim
- International Application: PCT/US2011/028690 WO 20110316
- Main IPC: C07C271/22
- IPC: C07C271/22
Abstract:
Polyplex formulations were prepared using p(TETA/CBA), its PEGylated analog, p(TETA/CBA)-g-PEG2k, and mixtures of the two species at 10/90 and 50/50 wt %, respectively. Increasing PEG wt % inhibited polyplex formation. This work demonstrates the feasibility of preparing homogenous polyplexes by altering the PEG wt % using a mixture of p(TETA/CBA) and p(TETA/CBA)-g-PEG2k products. Further, a single-step method of making p(TETA/CBA)-g-PEG2k is disclosed.
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