发明申请
- 专利标题： PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6
- 专利标题（中）： 作为CDK4 / 6的抑制剂的吡咯烷酮化合物
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申请号： US13579359申请日： 2011-02-17
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公开(公告)号： US20130150342A1公开(公告)日： 2013-06-13
- 发明人: Christopher Thomas Brain , Young Shin Cho , John William Giraldes , Bharat Lagu , Julian Roy Levell , Michael J. Luzzio , Lawrence Blas Perez , Yaping Wang , Fan Yang
- 申请人： Christopher Thomas Brain , Young Shin Cho , John William Giraldes , Bharat Lagu , Julian Roy Levell , Michael J. Luzzio , Lawrence Blas Perez , Yaping Wang , Fan Yang
- 申请人地址： CH Basel
- 专利权人： NOVARTIS AG
- 当前专利权人： NOVARTIS AG
- 当前专利权人地址： CH Basel
- 国际申请： PCT/EP11/52353 WO 20110217
- 主分类号： C07D498/20
- IPC分类号： C07D498/20 ; C07D498/08 ; C07D471/10 ; C07D487/04 ; C07D471/08 ; C07D487/08
摘要：
The invention is directed to novel pyrrolopyrimidine compounds of formula (I) wherein R1, R2Y, R4, R8-R11, A and L are defined herein and to salts, including pharmaceutically acceptable salts thereof. The compounds of the present invention are CDK4/6 inhibitors and could be useful in the treatment of diseases and disorders mediated by CDK4/6, such as cancer, including mantle cell lymphoma, liposarcoma, non small cell lung cancer, melanoma, squamous cell esophageal cancer and breast cancer. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CDK4/6 activity and to the treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
公开/授权文献
- US08957074B2 Pyrrolopyrimidine compounds as inhibitors of CDK4/6 公开/授权日：2015-02-17
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