发明申请
US20130150362A1 NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
有权
新戊酰胺[1,5-a]吡啶衍生物作为抑制剂
![NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS](/docs/US/2013-06-13/US20130150362A1/abs.jpg.600x600.jpg)
- 专利标题： NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
- 专利标题（中）： 新戊酰胺[1,5-a]吡啶衍生物作为抑制剂
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申请号： US13818177申请日： 2011-08-22
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公开(公告)号： US20130150362A1公开(公告)日： 2013-06-13
- 发明人: Lianyun Zhao , Duan Liu , Shuyi Tang , Amit K. Mandal , Umar Faruk Mansoor , Lalanthi Dilrukshi Vitharana , Panduranga Adulla P. Reddy , M. Arshad Siddiqui
- 申请人： Lianyun Zhao , Duan Liu , Shuyi Tang , Amit K. Mandal , Umar Faruk Mansoor , Lalanthi Dilrukshi Vitharana , Panduranga Adulla P. Reddy , M. Arshad Siddiqui
- 申请人地址： US NJ Rahway
- 专利权人： MERCK SHARP & DOHME CORP.
- 当前专利权人： MERCK SHARP & DOHME CORP.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US2011/048541 WO 20110822
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/519 ; A61K31/5377 ; A61K45/06
![NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS](/abs-image/US/2013/06/13/US20130150362A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to certain pyrazolo[1,5-a]pyrimidine compounds of Formula (I) as inhibitors of mammalian Target Of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP. The compounds may be used in the treatment of cancer and other disorders where mTOR is deregulated. The present invention further provides pharmaceutical compositions comprising the pyrazolo[1,5-a]pyrimidine compounds.
公开/授权文献
- US08883801B2 Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors 公开/授权日：2014-11-11