An oil pump control system for a vehicle, may include an oil pump configured to supply oil to an engine, an oil pressure control valve regulating oil pressure value of a discharging part in the oil pump, an oil pressure sensor sensing and outputting the oil pressure value of the discharging part in the oil pump, and a controller receiving a signal of the oil pressure value, determining a target oil pressure value of the discharging part in the oil pump in response to information relating to an oil pressure and operation state of the engine among vehicle information inputted from outside, comparing the sensed oil pressure value inputted from the oil pressure sensor with the target oil pressure value, and performing feedback control to drive the oil pressure control valve.