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发明申请
US20130158010A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA 有权
增加HYPOXIA诱导因子-1 ALPHA的稳定性的方法

METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA
摘要：
Disclosed herein are methods for controlling the activity of hypoxia-inducible transcription factor 1-alpha (HIF-1α) and diseases, conditions, or syndromes related thereto, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia. Further disclosed are pharmaceutical compositions comprising HIF-1α prolyl hydroxylase inhibitors useful in treating diseases, conditions, and/or syndromes related thereto the activity of HIF-1α.
摘要（中）：

本文公开了用于控制缺氧诱导型转录因子1-α（HIF-1α）的活性的方法以及与其相关的疾病，病症或综合征，特别是外周血管疾病（PVD），冠状动脉疾病（CAD），心脏 失败，缺血和贫血。 还公开了包含HIF-1α脯氨酰羟化酶抑制剂的药物组合物，其可用于治疗与其相关的HIF-1α活性的疾病，病症和/或综合征。

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