The present invention discloses a thin-film transistor liquid crystal display device, a substrate, and a manufacturing method. The thin-film transistor liquid crystal display device includes: a substrate and a signal line, a scan line, a pixel electrode, and a thin-film transistor that are formed on the substrate. The signal line and the scan line are arranged to intersect each other. The pixel electrode is located in a pixel display zone enclosed by the intersected signal line and scan line. The thin-film transistor includes a gate terminal, a source terminal, and a drain terminal. The gate terminal is electrically connected to the scan line. The drain terminal is electrically connected to the signal line. The source terminal is arranged at a position corresponding to the intersection of the signal line and the scan line and is electrically connected to the pixel electrode. With the above arrangement, the present invention can significantly reduce the amount of area of the pixel electrode occupied, increases the opening ratio of the pixel, and greatly reduces the influence on the alignment of the liquid crystal molecules thereby reducing asymmetry of the pixel quadrant and improving image quality.