Described are embodiments of methods, apparatuses, and systems for time synchronization of a multi-protocol I/O interconnect of computer apparatus. A method for synchronizing time across the multi-protocol I/O interconnect may include providing a first local time of a first switch of a switching fabric of a multi-protocol interconnect to a second switch of the switching fabric, and adjusting a second local time of the second switch to the first local time. Other embodiments may be described and claimed.