- 专利标题： COMPOUNDS AND METHODS FOR IMPROVING CELLULAR UPTAKE OF OLIGOMERIC COMPOUNDS
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申请号： US13658544申请日： 2012-10-23
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公开(公告)号： US20130164844A1公开(公告)日： 2013-06-27
- 发明人: Erich Koller , C. Frank Bennett
- 申请人： Isis Pharmaceuticals, Inc.
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 主分类号： C12Q1/02
- IPC分类号： C12Q1/02
摘要：
The present invention provides method of optimizing the efficacy and potency of antisense drugs. In certain embodiments, the invention provides assays useful for determining favorable oligonucleotide characteristics and excipeints for improved cellular uptake.
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