发明申请
- 专利标题: QUINAZOLINE COMPOUNDS AS KINASE INHIBITORS
- 专利标题(中): 喹唑啉化合物作为激酶抑制剂
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申请号: US13337863申请日: 2011-12-27
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公开(公告)号: US20130165458A1公开(公告)日: 2013-06-27
- 发明人: Jiann-Jyh Huang , Chu-Bin Liao , Pao-Nien Chen
- 申请人: Jiann-Jyh Huang , Chu-Bin Liao , Pao-Nien Chen
- 申请人地址: TW New Taipei City
- 专利权人: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
- 当前专利权人: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
- 当前专利权人地址: TW New Taipei City
- 主分类号: A61K31/517
- IPC分类号: A61K31/517 ; C07D401/12 ; C07D215/44 ; A61K31/4706 ; A61K31/4709 ; C12N9/99 ; A61P3/10 ; A61P13/12 ; A61P19/02 ; A61P37/00 ; A61P35/02 ; C07D239/94 ; A61P35/00
摘要:
A compound for treating protein kinase-related disease or disorder having a structure of formula (A): wherein X is N or CH; Y is NH, O, or CH2; Z is an aryl or a heteroaryl; and R1, R2, R3, and R4 are independently H, halo, nitro, cyano, aryl, heteroaryl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, —ORa, —C(O)Ra, —C(O)NRaRb, —NRaC(O)Rb, —NRaRb, —S(O)2Ra, —S(O)2NRa Rb, —NRaS(O)2Rb, —N═CRaRb, or —NRaC(O)NHRb, wherein each of Ra and Rb, independently, is H, alkyl, alkenyl, alkynyl, aryl, aryloxy, alkoxy, hydroxy, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl, or Ra and Rb, together with the nitrogen atom to which they are bonded, form heteroaryl, heterocycloalkyl, or heterocycloalkenyl; or R3 and R4 are as defined above, and R1 and R2 together with the carbons, to which they are attached, form a heterocycloalkenyl or heteroaryl.
公开/授权文献
- US08785459B2 Quinazoline compounds as kinase inhibitors 公开/授权日:2014-07-22