The present invention relates to a control device for an internal combustion engine including a first control subject (35D) capable of controlling two different control amounts (Pim and Regr) influencing each other at a low frequency and second control subjects (52 and 33) capable of controlling the control amount at a high frequency. In the present invention, the first control amount and the second control amount are changed by the first control subject, and the first control amount and the second control amount are changed by the second control subject. Further, in the present invention, an operation amount (Mv) is input to the first control subject so that a first control amount deviation component (ΔPimL) with respect to a target value changing at a low frequency and a second control amount deviation component (ΔRegrL) with respect to the target value become zero, and operation amounts (Megr and Mth) are input to the second control subject so that a first control amount deviation component (ΔPimH) with respect to a target value changing at a high frequency and a second control amount deviation component (ΔRegrH) with respect to the target value become zero.