发明申请
- 专利标题： SILENCING OF CSN5 GENE EXPRESSION USING INTERFERING RNA
- 专利标题（中）： 使用干扰RNA沉默CSN5基因表达
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申请号： US13551580申请日： 2012-07-17
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公开(公告)号： US20130178511A1公开(公告)日： 2013-07-11
- 发明人: Ian MacLachlan , Adam Judge , Snorri S. Thorgeirsson , Yun-Han Lee
- 申请人： Ian MacLachlan , Adam Judge , Snorri S. Thorgeirsson , Yun-Han Lee
- 申请人地址： US MD Bethesda CA Burnaby
- 专利权人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services,Protiva Biotherapeutics, Inc.
- 当前专利权人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services,Protiva Biotherapeutics, Inc.
- 当前专利权人地址： US MD Bethesda CA Burnaby
- 主分类号： C12N15/113
- IPC分类号： C12N15/113
摘要：
The present invention provides compositions comprising nucleic acids that target CSN5 gene expression and methods of using such compositions to silence CSN5 gene expression. More particularly, the present invention provides unmodified and chemically modified interfering RNA molecules which silence CSN5 gene expression and methods of use thereof, e.g., for treating cell proliferative disorders such as cancer. The present invention also provides nucleic acid-lipid particles that target CSN5 gene expression comprising an interfering RNA molecule, a cationic lipid, a non-cationic lipid, and optionally a conjugated lipid that inhibits aggregation of particles.
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