Systems and methods for adapting the performance of a wireless communication link with an implantable medical device (IMD) are disclosed. An illustrative method includes initiating a wireless link with the IMD, measuring an initial performance of the wireless link, determining whether the initial performance of the wireless link is adequate, adjusting an operating parameter related to the wireless link in the event the initial performance of the wireless link is inadequate, measuring a performance of the wireless link in response to the adjusted operating parameter, and setting the operating parameter to a prior setting if the measured performance of the wireless link does not improve in response to the adjusted operating parameter.