A cache module leverages a logical address space and storage metadata of a storage module (e.g., virtual storage module) to cache data of a backing store. The cache module maintains access metadata to track access characteristics of logical identifiers in the logical address space, including accesses pertaining to data that is not currently in the cache. The access metadata may be separate from the storage metadata maintained by the storage module. The cache module may calculate a performance metric of the cache based on profiling metadata, which may include portions of the access metadata. The cache module may determine predictive performance metrics of different cache configurations. An optimal cache configuration may be identified based on the predictive performance metrics.