- 专利标题: NOVEL METHOD OF PROGNOSIS ASSOCIATED WITH CASES OF POSTPARTUM HEMORRHAGE
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申请号: US13057633申请日: 2009-08-06
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公开(公告)号: US20130190585A1公开(公告)日: 2013-07-25
- 发明人: Alexandre Mebazaa , Etienne Gayat , Matthieu Resche-Rigon , Olivier Morel , Yann Fargeaudou , Matthias Rossignol , Didier Payen
- 申请人: Alexandre Mebazaa , Etienne Gayat , Matthieu Resche-Rigon , Olivier Morel , Yann Fargeaudou , Matthias Rossignol , Didier Payen
- 优先权: FR0855454 20080806
- 国际申请: PCT/EP2009/060240 WO 20090806
- 主分类号: A61B5/00
- IPC分类号: A61B5/00
摘要:
The present invention relates to an in vitro method of prognosis for the arrest of bleeding in a patient suffering from postpartum haemorrhage in the absence of an invasive procedure, comprising the following steps: (a) determining, using a biological sample from said patient, the plasma fibrinogen concentration, the blood troponin concentration and also the prothrombin time; (b) studying at least two clinical markers for said patient, selected from the group comprising heart rate and the presence of placentation abnormalities; (c) calculating a score Z according to the following equation: Z=a+b+v+d+e; where a is associated with the existence of placentation abnormalities in said patient, with a being 0 when no placentation abnormality is observed in said patient and a being 1 when one or more placentation abnormalities are observed in said patient; where b is associated with the heart rate of said patient, with b being 0 when the heart rate of said patient is less than or equal to 115 bpm (beats per minute) and b being 1 when the heart rate is greater than 115 bpm; where c is associated with the plasma fibrinogen concentration of said patient, with c being 0 when said concentration is greater than or equal to 2 g/L and c being 1 when said concentration is less than 2 g/L; where d is associated with the blood troponin concentration of said patient, with d being 0 when said concentration is less than the detection cut-off and d being 1 when said concentration is grater than or equal to the detection cut-off; where e is associated with the prothrombin time (PT) of said patient, with e being 0 when said prothrombin time is greater than or equal to 50% and e being 1 when said prothrombin time is less than 50%; where a score Z of greater than or equal to a value of 2 is an indication of the need to perform an invasive procedure in order to stop the bleeding in said patient suffering from postpartum haemorrhage.
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