Systems and methods for improving the timing alignment of 25% duty cycle non-overlapping waveforms are provided. A representative system includes a waveform synthesizer that generates a plurality of 25% duty cycle input waveforms and inverters that receive the input waveforms at the inputs of the inverters and invert the input waveforms, producing a plurality of inverted waveforms at the outputs of the inverters. The system also includes NOR gates that receive the plurality of inverted waveforms at the inputs of the NOR gates and pass through one of the inverted waveforms at the outputs of the NOR gates responsive to three inverted waveforms of the plurality of inverted waveforms being at logic “0”; and mixers having inputs that receive the pass-through waveform and a first radio frequency (RF) signal, wherein the mixers combine the pass-through waveform and the RF signal into an output signal.