发明申请
- 专利标题： ANTIBODIES AGAINST HUMAN IL17 AND USES THEREOF
- 专利标题（中）： 抗体人类IL17抗体及其用途
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申请号： US13186109申请日： 2011-07-19
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公开(公告)号： US20130195844A1公开(公告)日： 2013-08-01
- 发明人: Johannes Auer , Nikolaos Dimoudis , Guy Georges , Petra Hanke , Hendrik Knoetgen , Ekkehard Moessner , Claire Louise Langrish
- 申请人： Johannes Auer , Nikolaos Dimoudis , Guy Georges , Petra Hanke , Hendrik Knoetgen , Ekkehard Moessner , Claire Louise Langrish
- 专利权人： ROCHE PALO ALTO LLC.
- 当前专利权人： ROCHE PALO ALTO LLC.
- 优先权： EP08017155.6 20080929
- 主分类号： C07K16/24
- IPC分类号： C07K16/24
摘要：
An antibody binding to IL-17 characterized by binding to the same IL-17 epitope to which monoclonal antibody 3C1 binds, and being of human IgG1 isotype modified in the hinge region at amino acid position 216-240, preferably at amino acid position 220-240, between CH1 and CH2 and/or in the second inter-domain region at amino acid position 327-331 between CH2 and CH3 has advantageous properties for the treatment of inflammatory diseases.
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