发明申请
- 专利标题： ANTIBODY AGAINST HUMAN PROSTAGLANDIN E2 RECEPTOR EP4
- 专利标题（中）： 针对人PROSTAGLANDIN E2受体EP4的抗体
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申请号： US13876763申请日： 2011-09-28
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公开(公告)号： US20130197199A1公开(公告)日： 2013-08-01
- 发明人: Kiyoshi Takayama , Tomoko Shimizu , Yuji Urushibata , Yukihiko Sugimoto
- 申请人： Kiyoshi Takayama , Tomoko Shimizu , Yuji Urushibata , Yukihiko Sugimoto
- 申请人地址： JP Kumamoto-shi, Kumamoto JP Sapporo-shi, Hokkaido
- 专利权人： NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY,NB HEALTH LABORATORY CO., LTD.
- 当前专利权人： NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY,NB HEALTH LABORATORY CO., LTD.
- 当前专利权人地址： JP Kumamoto-shi, Kumamoto JP Sapporo-shi, Hokkaido
- 优先权： JP2010-218158 20100929
- 国际申请： PCT/JP2011/072190 WO 20110928
- 主分类号： C07K16/28
- IPC分类号： C07K16/28
摘要：
It is an object of the present invention to provide an antibody that binds to a human PGE2 receptor subtype EP4 and inhibits the function of EP4, or a functional fragment thereof. It is another object of the present invention to provide a medicament comprising the aforementioned antibody or a functional fragment thereof. Mice were immunized with the human PGE2 receptor subtype EP4, and a monoclonal antibody that suppresses the intracellular cAMP level increase induced by EP4 was screened. In addition, the CDR sequences of the obtained monoclonal antibody were determined.
公开/授权文献
- US09175080B2 Antibody against human prostaglandin E2 receptor EP4 公开/授权日：2015-11-03
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