Provided is a pain signal measurement device including a microprobe array inserted into a skin to measure a pain signal. The microprobe array includes a guard electrode disposed on a substrate; a plurality of microprobes penetrating the substrate and the guard electrode, electrically insulated from the guard electrode, and measuring a voltage or current of the skin into which the microprobe array is inserted; and an insulating layer disposed between the guard electrode and a guarded electrode of each of the microprobes to reduce a noise between the microprobes. A surface of the insulating layer of each of the microprobes is grounded to the guard electrode.