发明申请
US20130203726A1 FtsZ INHIBITORS AS POTENTIATORS OF BETA-LACTAM ANTIBIOTICS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS
审中-公开
FtsZ抑制剂作为抗甲氧西林硫杆菌抗菌素抗肿瘤药物的潜力
- 专利标题： FtsZ INHIBITORS AS POTENTIATORS OF BETA-LACTAM ANTIBIOTICS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS
- 专利标题（中）： FtsZ抑制剂作为抗甲氧西林硫杆菌抗菌素抗肿瘤药物的潜力
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申请号： US13583480申请日： 2011-03-04
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公开(公告)号： US20130203726A1公开(公告)日： 2013-08-08
- 发明人: Terry Roemer , Sang Ho Lee , Lisa Wang Jarantow
- 申请人： Terry Roemer , Sang Ho Lee , Lisa Wang Jarantow
- 国际申请： PCT/US11/27136 WO 20110304
- 主分类号： A61K31/545
- IPC分类号： A61K31/545 ; A61K31/397 ; A61K31/4025 ; A61K31/437
摘要：
The present invention relates to the use of inhibitors of FtsZ, an ancestral tubulin of prokaryotes, to restore susceptibility to β-lactam antibiotics, including carbapenems and cephalosporins, particularly in methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphyloccus epidermis (MRSE), and other coagulase negative staphylococci (MRCNS).