发明申请
- 专利标题: Optimized Fc Variants
- 专利标题(中): 优化的Fc变体
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申请号: US13764693申请日: 2013-02-11
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公开(公告)号: US20130209457A1公开(公告)日: 2013-08-15
- 发明人: Gregory Alan Lazar , Wei Dang , John Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
- 申请人: Gregory Alan Lazar , Wei Dang , John Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
- 申请人地址: US CA Monrovia
- 专利权人: Xencor, Inc.
- 当前专利权人: Xencor, Inc.
- 当前专利权人地址: US CA Monrovia
- 主分类号: C07K16/28
- IPC分类号: C07K16/28
摘要:
The present invention relates to a variant Fc region comprising an amino acid substitution at position 238 of the Fc region as compared to a human parent Fc region, wherein the variant Fc region comprises a 238D substitution, wherein the variant Fc region binds FcγRIIb with increased binding affinity compared to a human parent Fc region.
公开/授权文献
- US09051373B2 Optimized Fc variants 公开/授权日:2015-06-09
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