发明申请
US20130210928A1 NOVEL BIPHENYL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARING NOVEL BIPHENYL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING DIABETES COMPLICATIONS
有权
新型联苯化合物或其药学上可接受的盐,制备新型联苯化合物或其药学上可接受的盐的方法,以及含有作为活性成分的药物组合物,用于预防或治疗糖尿病并发症
- 专利标题: NOVEL BIPHENYL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARING NOVEL BIPHENYL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING DIABETES COMPLICATIONS
- 专利标题(中): 新型联苯化合物或其药学上可接受的盐,制备新型联苯化合物或其药学上可接受的盐的方法,以及含有作为活性成分的药物组合物,用于预防或治疗糖尿病并发症
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申请号: US13816402申请日: 2011-08-11
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公开(公告)号: US20130210928A1公开(公告)日: 2013-08-15
- 发明人: Jin Sook Kim , Young Sook Kim , Jung Hyun Kim , Eun Jin Shon , Ki Mo Kim , Chan-sik Kim , Dong Ho Jung , Yun Mi Lee , Kyu Hyung Jo , Ohn Soon Kim , Nam-Hee Yoo
- 申请人: Jin Sook Kim , Young Sook Kim , Jung Hyun Kim , Eun Jin Shon , Ki Mo Kim , Chan-sik Kim , Dong Ho Jung , Yun Mi Lee , Kyu Hyung Jo , Ohn Soon Kim , Nam-Hee Yoo
- 申请人地址: KR Daejeon
- 专利权人: KOREA INSTITUTE OF ORIENTAL MEDICINE
- 当前专利权人: KOREA INSTITUTE OF ORIENTAL MEDICINE
- 当前专利权人地址: KR Daejeon
- 优先权: KR10-2010-0077117 20100811; KR10-2011-0079856 20110810
- 国际申请: PCT/KR2011/005913 WO 20110811
- 主分类号: C07C43/23
- IPC分类号: C07C43/23 ; C07C41/38
摘要:
The present invention provides a novel biphenyl compound or pharmaceutically acceptable salts thereof, methods for preparing the same, and pharmaceutical compositions for preventing or treating diabetic complications containing the same as an active ingredient. Novel biphenyl compounds, according to the present invention, effectively suppress generation activity of advanced glycation end products, which cause diabetic complications and are a criterion for evaluating the effectiveness of a treating agent for diabetic complications, and show an excellent therapeutic effect on retina blood vessels, increased occludin, and decreased angiogenic growth factor in actual diabetic retinopathy induced retina. Thus, novel biphenyl compounds according to the present invention can be used effectively as an active ingredient in compositions for preventing or treating diabetic complications such as diabetic retinopathy.