发明申请
US20130211079A1 SUBSTITUTED HETEROCYCLES AS THERAPEUTIC AGENTS FOR TREATING CANCER
审中-公开
作为治疗癌症的治疗药物的替代治疗剂
- 专利标题： SUBSTITUTED HETEROCYCLES AS THERAPEUTIC AGENTS FOR TREATING CANCER
- 专利标题（中）： 作为治疗癌症的治疗药物的替代治疗剂
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申请号： US13841648申请日： 2013-03-15
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公开(公告)号： US20130211079A1公开(公告)日： 2013-08-15
- 发明人: Alexander DOEMLING
- 申请人： Alexander DOEMLING
- 主分类号： C07D233/28
- IPC分类号： C07D233/28 ; C07D401/12 ; C07D403/12 ; C07D413/12
摘要：
MDM2 and MDM4 proteins prevent apoptosis of cancer cells by negatively regulating the transcription factor p53. Compounds according to Formula I are selective antagonists of MDM2 and MDM4 proteins, disrupting the p53/MDM2 and p53/MDM4 complex. These compounds therefore are candidate therapeutics for treating cancer as well as other cell proliferative disease states.