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发明申请
US20130216479A1 SITE-SPECIFIC CHEMICAL MODIFICATION OF PROTEINS AT THEIR N-TERMINI, ENABLING THE FORMATION OF HOMOGENEOUS ADDUCTS 审中-公开
蛋白质在其N-末端的特异性化学修饰，启动均质添加物的形成

  • 专利标题： SITE-SPECIFIC CHEMICAL MODIFICATION OF PROTEINS AT THEIR N-TERMINI, ENABLING THE FORMATION OF HOMOGENEOUS ADDUCTS
  • 专利标题（中）： 蛋白质在其N-末端的特异性化学修饰，启动均质添加物的形成
  • 申请号： US13854634
    申请日： 2013-04-01
  • 公开(公告)号： US20130216479A1
    公开(公告)日： 2013-08-22
  • 发明人: Alexander Krantz , Peng Yu
  • 申请人： Alexander Krantz , Peng Yu
  • 主分类号： C07K1/107
  • IPC分类号： C07K1/107 ;  C07K14/47 ;  C07K14/575
SITE-SPECIFIC CHEMICAL MODIFICATION OF PROTEINS AT THEIR N-TERMINI, ENABLING THE FORMATION OF HOMOGENEOUS ADDUCTS
摘要：
Site-specific modifications of proteins at their N-termini are provided. In particular, a chemical modification of proteins at their N-termini via a transamination reaction to form homogeneous adducts such as, the corresponding oxime derivatives is provided. Methods of making and using the adducts in radio-labelling, molecular imaging applications, and treatment of disorders such as cancer, Crohn's disease, arthritis, atherothrombosis and plaque rupture are also provided.
摘要（中）：

提供蛋白质在其N-末端的位点特异性修饰。 特别地，提供了通过转氨基反应在其N-末端进行蛋白质的化学修饰以形成均匀的加合物，例如相应的肟衍生物。 还提供了在放射性标记，分子成像应用中制备和使用加合物的方法以及诸如癌症，克罗恩病，关节炎，动脉粥样硬化血栓形成和斑块破裂等疾病的治疗方法。

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