发明申请
US20130217756A1 RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
有权
RNA干扰介导的使用短暂干扰核酸的基因表达的抑制（siNA）
- 专利标题： RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
- 专利标题（中）： RNA干扰介导的使用短暂干扰核酸的基因表达的抑制（siNA）
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申请号： US13881415申请日： 2011-10-25
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公开(公告)号： US20130217756A1公开(公告)日： 2013-08-22
- 发明人: Mark Cancilla , James John Cunningham , Michael W. Flanagan , Henry J. Haringsma , Denise M. Kenski , Matthew G. Stanton , Steven M. Stirdivant , Aarron T. Willingham
- 申请人： Mark Cancilla , James John Cunningham , Michael W. Flanagan , Henry J. Haringsma , Denise M. Kenski , Matthew G. Stanton , Steven M. Stirdivant , Aarron T. Willingham
- 申请人地址： US NJ Rahway
- 专利权人： MERCK SHARP & DOHME CORP.
- 当前专利权人： MERCK SHARP & DOHME CORP.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US2011/057663 WO 20111025
- 主分类号： C07H21/02
- IPC分类号： C07H21/02
摘要：
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.
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