Systems and method are provided that allow an application layer client in a mobile device to manage multiple interfaces in a communication network. The multiple interfaces can include WiFi, cellular, Femto, WiMAX, Bluetooth, infrared, Ethernet, and other types of interfaces for communication in a network. The client on the mobile device can use intelligence and rules to determine how and when request fragments are communicated over the various interfaces available to the client. The intelligence can include parameters such as performance information for a particular interface and subscriber preferences. Based on this information the client can decide to use a combination of the interfaces to obtain multimedia content and render the content for display on the mobile device. By using a combination of interfaces and tracking the advantages and disadvantages of each interface, the client can make intelligent decisions in providing multimedia content to the user.