A multi-protocol switching control system suitable for controlling different electronic devices of different protocols by using a router capable of receiving different kinds of protocol to instruct switch sets connected thereto. The system comprises: a wireless router for controlling at least one switch set; the switch set receiving control signals from the central controller for turning on or off electronic devices connected thereto. A protocol area is defined in the router and includes at least two control protocols. The switch control unit defines a protocol assign function to the protocol area. The function causes that one can define or input a protocol to the protocol area and assign the protocol as an operating protocol of the system so that the operation protocols in the wireless routers are matched to those used in switch sets; thereby, the system can receive external instructions and instruct the switch sets to perfume predetermined operations.