发明申请
- 专利标题： TRUNCATED L1 PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE 52
- 专利标题（中）： 人类羊毛病类型52的截短的L1蛋白
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申请号： US13807858申请日： 2011-07-01
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公开(公告)号： US20130230548A1公开(公告)日： 2013-09-05
- 发明人: Shaowei Li , Xiaobing Mo , Minxi Wei , Huirong Pan , Jun Zhang , Ningshao Xia
- 申请人： Shaowei Li , Xiaobing Mo , Minxi Wei , Huirong Pan , Jun Zhang , Ningshao Xia
- 申请人地址： CN Siming District, Xiamen, Fujian Province
- 专利权人： XIAMEN UNIVERSITY
- 当前专利权人： XIAMEN UNIVERSITY
- 当前专利权人地址： CN Siming District, Xiamen, Fujian Province
- 优先权： CN201010216189.X 20100702
- 国际申请： PCT/CN2011/076763 WO 20110701
- 主分类号： C07K14/025
- IPC分类号： C07K14/025 ; C12P21/02
摘要：
Provided is a truncated L1 protein of Human Papillomavirus (HPV) Type 52 which, compared to a wild type HPV52 L1 protein, is truncated by 27-42 amino acids at the N-terminal. Also provided are a coding sequence of the truncated HPV52 L1 protein, a virus-like particle (VLP) comprising the protein, and a method of preparing the protein and the VLP using an E. coli expression system. The truncated HPV52 L1 protein and an assembled VLP can be used to prevent an HPV52 infection and a disease caused by HPV52 infection, such as cervical cancer.
公开/授权文献
- US09499591B2 Truncated L1 protein of human papillomavirus type 52 公开/授权日：2016-11-22
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