发明申请
- 专利标题: METHOD OF TREATMENT WITH BRAF INHIBITOR
- 专利标题(中): 用BRAF抑制剂处理的方法
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申请号: US13988116申请日: 2011-11-18
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公开(公告)号: US20130231347A1公开(公告)日: 2013-09-05
- 发明人: Maureen Bleam , Tona M. Gilmer , James G. Greger , Sylvie G. Laquerre , Li Liu
- 申请人: Maureen Bleam , Tona M. Gilmer , James G. Greger , Sylvie G. Laquerre , Li Liu
- 申请人地址: GB Middlesex
- 专利权人: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
- 当前专利权人: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
- 当前专利权人地址: GB Middlesex
- 国际申请: PCT/US11/61408 WO 20111118
- 主分类号: A61K31/519
- IPC分类号: A61K31/519 ; A61K45/06 ; A61K31/437 ; A61K31/501 ; A61K31/506
摘要:
The disclosure is directed to a method of treating humans suffering from V600 mutant melanoma that incorporates the detection of the presence or absence of at least one mutation in at least one NRAS protein and/or at least one MEK1 protein, or a gene encoding said protein, and subsequently initiating treatment, modifying treatment, or discontinuing treatment with a chemo-therapeutic agent selected from a BRaf inhibitor or other suitable agent based upon the presence or absence of said mutation.