发明申请
US20130237545A1 PYRIDAZINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING COGNITIVE IMPAIRMENT
有权
吡咯烷酮衍生物，组合物和治疗认知障碍的方法
- 专利标题： PYRIDAZINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING COGNITIVE IMPAIRMENT
- 专利标题（中）： 吡咯烷酮衍生物，组合物和治疗认知障碍的方法
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申请号： US13885569申请日： 2011-11-15
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公开(公告)号： US20130237545A1公开(公告)日： 2013-09-12
- 发明人: John A. Lowe, III
- 申请人： John A. Lowe, III
- 申请人地址： US IN Indianapolis
- 专利权人： AGENEBIO, INC.
- 当前专利权人： AGENEBIO, INC.
- 当前专利权人地址： US IN Indianapolis
- 国际申请： PCT/US11/60854 WO 20111115
- 主分类号： C07D237/24
- IPC分类号： C07D237/24 ; C07D413/14 ; C07D413/04 ; C07D401/04 ; C07D403/04
摘要：
This invention relates to pyridazine derivatives, compositions comprising therapeutically effective amounts of those pyridazine derivatives and methods of using those derivatives or compositions in treating central nervous system (CNS) disorders with cognitive impairment that are responsive to agonists of α5 subunit containing GABAA receptor, e.g., age-related cognitive impairment, Mild Cognitive Impairment (MCI), dementia, Alzheimer's Disease (AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia and cancer-therapy-related cognitive impairment.
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